Novel PPAR-γ agonists have been designed and docking studies of the compounds have been performed. The pharmacophore having phenoxy linker and TZD ring has been retained and the lipophilic tail has been modified by various fatty acids. The designed ligands show mainly vander wall’s interactions and hydrogen bonding. All the designed compounds show good binding with the receptor. The designed ligands promise to be potent ligands for antihyperglycemic evaluation.
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